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ICN2 Thesis Defence: Xiaoman Mao
Title: Platinum-based Nanostructured Polymers for Glioblastoma Treatment

Directors: Prof. Daniel Ruiz Molina, Dr Fernando Novio, ICN2 Nanostructured Functional Materials Group

Abstract:
Nanostructured Coordination polymers (NCPs) have emerged as a new family of nanoparticles with interesting properties due to the versatility of coordination chemistry. The potential multifunctionality of these nanosystems and the facility for the modification of their physicochemical properties open new perspectives in different fields, including medicine. The recent advances have showed the potentiality of NCPs as smart drug delivery systems, bioimaging probes or a combination of both.

This Thesis has been focused in the design, synthesis and characterization of platinum-based NCPs for exploring the possibilities of these nanosystems in the treatment of cancer, and in particular in the treatment of glioblastoma. Different platinum-based coordination polymers have been obtained and evaluated for the biomedical use based on different studies in silico, in vitro and in vivo. The synthetic methodology, the proper selection of precursors and reaction conditions, and the study of the final physicochemical and biological properties have centered the work carried out.

Apr 16, 2021 11:00 AM in Madrid

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